Pharmacological action Lopid 600 mg
Lopid – lowering drugs, fibric acid derivative. Reduces blood levels of triglycerides, total cholesterol, VLDL and to a lesser extent, LDL. It appears that the main mechanism of action is to activate lipoprotein lipase. Inhibits peripheral lipolysis, increases the excretion of liver free fatty acids, thus reducing the synthesis of triglycerides in the liver. Reduces the incorporation of long chain fatty acids in newly synthesized triglycerides, accelerate turnover and removal of cholesterol from the liver and increases its excretion in the bile. Inhibits the synthesis of VLDL and increase their clearance. Increases the formation of HDL, have anti-atherogenic effect.
Onset of action – after 2-5 days, the maximum therapeutic effect develops within 4 weeks.
Pharmacokinetics Lopid 600 mg
Gemfibrozil is well absorbed from the gastrointestinal tract after oral administration, Cmax achieved within 1-2 h.
T1 / 2 after a single dose of 1.5 h after administration of multiple doses – 1.3 h. Write to the kidneys (70%), unchanged in 6% – in the bile.
Dosage Lopid 600 mg
Inside – 600 mg 2 times / day (morning and evening), or 900 mg 1 time / day (evening). Are 30 minutes before eating. The course of treatment – a few months, if necessary, conduct refresher courses.
The maximum daily dose is 1.5 g.
Drug Interactions Lopid 600 mg
While the use of antacids reduce the absorption of gemfibrozil in the gastrointestinal tract.
When applied simultaneously amplified the effects of indirect anticoagulants and oral hypoglycemic agents sulfonylureas.
While the use of atorvastatin, lovastatin, simvastatin, cerivastatin increased risk of severe myopathy, especially while the use of lovastatin or cerivastatin.
With the simultaneous use of carbamazepine described cases of increasing concentrations of carbamazepine in plasma, which can lead to their increased side effects.
At the same time taking colestipol and gemfibrozil gemfibrozil reduced absorption.
While the use of cyclosporin been described to reduce absorption and concentration of cyclosporine in the blood plasma.
Pregnancy and lactation Lopid 600 mg
Gemfibrozil is contraindicated during pregnancy and lactation (breastfeeding).
Side effects Lopid 600 mg
From the digestive system: dry mouth, loss of appetite, heartburn, nausea, vomiting, gastralgia, abdominal pain, bloating, diarrhea or constipation, hyperbilirubinemia, elevated liver transaminases and alkaline phosphatase, cholelithiasis.
From the central and peripheral nervous system: dizziness, headache, excessive fatigue, fainting, paresthesia, somnolence, and depression.
On the part of the musculoskeletal system: muscle pain, muscle weakness, arthralgia, synovitis, rhabdomyolysis.
From the hemopoietic system: leucopenia, anemia, bone marrow hypoplasia.
From the laboratory parameters: hypokalemia.
Dermatological reactions: alopecia.
Allergic reactions: skin rash, dermatitis.
Other: hypokalemia, alopecia, impaired vision, reduced potency and / or libido.
Statement Lopid 600 mg
Hyperlipoproteinemia IIb, IV and V types, which are corrected is not a special diet and physical activity, especially in the presence of other risk factors, secondary hyperlipoproteinemia due to illness, are difficult to care (diabetes, gout, hypothyroidism).
Contraindications Lopid 600 mg
Severe liver disease (including primary biliary cirrhosis), gallstones, chronic cholecystitis, renal failure, severe, pregnancy, lactation, concomitant use of lovastatin, hypersensitivity to gemfibrozil.
Cautions
In the treatment of gemfibrozil should systematically monitor the content of lipids in the blood. If the 3-month course of treatment has not led to a decrease in blood lipids, gemfibrozil should be discontinued.
